Improving performance of polygenic risk scores for hypertension across two ancestry groups.
Marguerite R. Irvin, Vinodh Srinivasasainagendra, Nicole D. Armstrong…·Hemant K. Tiwari
This paper compares two Bayesian methods for polygenic risk scores (PRS) for hypertension across two ancestry groups, finding improved performance with updated LD panels and functional annotations, but not equitable results between groups.