Disrupting the Feed-Forward Cycle of RyR1 Calcium Leak and Oxidative Stress Mitigates Doxorubicin-Induced Skeletal Myopathy
Lourdes Figueroa, Eshwar Reddy Tammineni, Pablo Marco‐Moreno, Ainara Vallejo‐Illarramendi, Adolfo López de Munain, Maialen Sagartzazu‐Aizpurua, Michael Fill, Carlo D. Manno
This study shows that doxorubicin causes skeletal muscle weakness by disrupting RyR1 calcium leak and oxidative stress, and that stabilizing the RyR1-FKBP12 complex with triazole compounds mitigates these effects.
American Journal of Physiology-Cell Physiology · May 19, 2026Peer-reviewedPhysiology