Author

Giulio Frontino

IRCCS Ospedale San RaffaeleORCID 0000-0002-6115-2476Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Fabio ManentiiD· 2 shared Federica CuozzoiD· 2 shared Gabriel SiracusanoiD· 2 shared Lorenzo PiemontiiD· 2 shared Raniero ChimientiiD· 2 shared Riccardo BonfantiiD· 2 shared Valentina ZamarianiD· 2 shared Valeria SordiiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Fabio ManentiORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional WFS1 variant

Silvia Torchio, Gabriel Siracusano, Federica Cuozzo, Valentina Zamarian, Silvia Pellegrini, Fabio Manenti, Riccardo Bonfanti, Giulio Frontino, Valeria Sordi, Raniero Chimienti, Lorenzo Piemonti

This study shows liraglutide treatment restores glucose-stimulated insulin secretion and reduces apoptosis in WFS1 mutant iPSC-derived β cells.

Diabetes · Apr 9, 2025Peer-reviewedCell Biology

A WFS1 variant disrupting acceptor splice site uncovers the impact of alternative splicing on β cell apoptosis in a patient with Wolfram syndrome.

Raniero Chimienti, Silvia Torchio, Gabriel Siracusano, Valentina Zamarian, Laura Monaco, Marta Tiffany Lombardo, Silvia Pellegrini, Fabio Manenti, Federica Cuozzo, Greta Rossi, Paola Carrera, Valeria Sordi, Vania Broccoli, Riccardo Bonfanti, Giorgio Casari, , Lorenzo Piemonti

This study investigates how a WFS1 splice site mutation affects β cell apoptosis in Wolfram syndrome by analyzing alternative splicing and functional consequences in patient-derived iPSCs.

bioRxiv · Dec 29, 2023 · PreprintGenetics