Author

Leonid A. Pobezinsky

University of Massachusetts AmherstORCID 0000-0002-6115-3559Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Adam C. LynchiD· 2 shared Elena L. PobezinskayaiD· 2 shared Kaito A. HiokiiD· 2 shared Xueting LiangiD· 2 shared Chinmayee Mehta· 1 shared Colleen M. HadiganiD· 1 shared Cooper JamesiD· 1 shared Dominique AlfandariiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

Adam C. LynchORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Angiogenic CD8 T cells from PWH induce Granzymes-dependent PAR1 activation promoting endothelial inflammation

Tong Li, Chinmayee Mehta, Cooper James, Jinya Chen, Hui Chen, Gerard P. Ahern, Ziang Zhu, Maitane Faus Cid, Maryam Abdussamad, Shiwen Yu, Jai Kumar, Princy N. Kumar, Colleen M. Hadigan, Kyle A. DiVito, Dorian B. McGavern, , Marta Catálfamo

The paper identifies CD8 T cells in HIV-positive individuals that promote endothelial inflammation via granzyme-dependent PAR1 activation, linking immune activation to cardiovascular risk.

bioRxiv · Aug 6, 2025 · PreprintImmunology

Heterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages.

Kaito A. Hioki, Xueting Liang, Adam C. Lynch, Ravi Ranjan, Elena L. Pobezinskaya, Leonid A. Pobezinsky

The paper identifies memory-like and effector-like CD8αα intraepithelial lymphocytes in both TCRαβ and TCRγδ lineages, showing transcriptional conservation and distinct developmental origins.

bioRxiv · May 20, 2025 · PreprintImmunology

A Dapl1+ subpopulation of naive CD8 T cells contains committed precursors of memory lineage.

Adam C. Lynch, Kaito A. Hioki, Xueting Liang, Iris Thesmar, Julia Cernjul, Xin‐Jian He, Jesse Mager, Wei Cui, Dominique Alfandari, Elena L. Pobezinskaya, Leonid A. Pobezinsky

The paper identifies a Dapl1+ subset of naive CD8 T cells that are pre-programmed to differentiate into memory-like T cells.

bioRxiv · Feb 6, 2025 · PreprintImmunology