Author

Andrew F. Taylor

Fred Hutch Cancer CenterORCID 0000-0002-6124-2930Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

Gerald R. SmithiD· 2 shared Ahmet KarabulutiD· 1 shared Ryan T. CirziD· 1 shared Susan K. AmundseniD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersMolecular Biology

Gerald R. SmithORCID

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2 papers

Recent·Most cited

Molecular BiologyScientific ReportsPeer-reviewedNov 5, 2020

Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling

Susan K. Amundsen, Andrew F. Taylor, Gerald R. Smith

The paper investigates how the Chi recombination hotspot controls the RecBCD helicase-nuclease through long-range intramolecular signaling, identifying mutations that disrupt this communication pathway.

15 citations

experimental assay

𝕏 PostBluesky

Molecular BiologyNucleic Acids ResearchPeer-reviewedJun 10, 2020

Small-molecule sensitization of RecBCD helicase-nuclease to a Chi hotspot-activated state

Ahmet Karabulut, Ryan T. Cirz, Andrew F. Taylor, Gerald R. Smith

The paper shows that the small molecule NSAC1003 mimics Chi sites, sensitizing RecBCD to cut DNA at Chi-independent positions, revealing a mechanism for RecBCD regulation.

11 citations

experimental assay

𝕏 PostBluesky