Molecular BiologyNucleic Acids ResearchPeer-reviewed
Small-molecule sensitization of RecBCD helicase-nuclease to a Chi hotspot-activated state
Ahmet Karabulut, Ryan T. Cirz, Andrew F. Taylor, Gerald R. Smith
The paper shows that the small molecule NSAC1003 mimics Chi sites, sensitizing RecBCD to cut DNA at Chi-independent positions, revealing a mechanism for RecBCD regulation.
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