Nicholas Miller Gregg

Electrical perturbation reveals a directional architecture for communication across human visual streams

The paper uses electrical stimulation to map directional connectivity in human visual cortex, revealing an asymmetric architecture of interareal influence.

White matter conduction in the human brain is mostly slow, with rare high velocity connections

The paper measures conduction velocities in human white matter bundles using dMRI tractography and intracranial stimulation, finding high variability and a predominance of slow connections.

Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex

This study shows that single electrical pulses in white matter modulate visual evoked potentials but not broadband responses, suggesting additive noise effects and enhanced visual input synchrony.

Kainic Acid Pig Model of Hippocampal Epilepsy

This paper develops a porcine model of mesial temporal lobe epilepsy using kainic acid and an implantable device to study seizures and electrophysiological features.

Insulotaxy: Navigating the Human Insula with a Novel Stereotactic Framework

This paper introduces a novel stereotactic coordinate system for the insula to improve surgical targeting and outcome assessment by accounting for individual anatomical variability.

Approximating Signal Sources in Stereo-EEG Single Pulse Electrical Stimulation using Re-referencing and Spectral Analysis

The paper compares re-referencing and spectral analysis techniques to estimate BSEP source locations in sEEG data from human subjects.

Proper reference selection and re-referencing to mitigate bias in single pulse electrical stimulation data

The paper identifies reference contamination in single pulse electrical stimulation data and provides strategies to detect and mitigate it through re-referencing or data recollection.

Human pulvinar stimulation engages select cortical pathways in epilepsy

This study shows that electrical stimulation of different pulvinar subregions in epilepsy patients evokes distinct patterns of brain activity in occipital, parietal, and temporal areas.

Method for cycle detection in sparse, irregularly sampled, long-term neuro-behavioral timeseries: Basis pursuit denoising with polynomial detrending of long-term, inter-ictal epileptiform activity

The paper develops a method to detect cycles in sparse, irregularly sampled neuro-behavioral timeseries using basis pursuit denoising with polynomial detrending, validated on epileptiform discharge data.

ER-detect: a pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data

ER-detect automates the detection of early evoked responses in iEEG data, achieving performance comparable to inter-rater reliability.

Signatures of electrical stimulation driven network interactions in the human limbic system

The paper identifies unique stimulation-evoked waveforms in distinct limbic subsystems using intracranial recordings, suggesting potential biomarkers for limbic network function.

Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation

This paper introduces a method to quantify and compare brain stimulation response shapes using canonical response parameterization, enabling statistical analysis of single-pulse intracranial electrical stimulation data.

Electrical stimulation of temporal and limbic circuitry produces distinct responses in human ventral temporal cortex

This study uses electrical stimulation to identify distinct electrophysiological responses in the human ventral temporal cortex, revealing different input connectivity profiles from cortical and limbic regions.

Chronic modulation of human memory and thalamic-hippocampal theta activities.

The paper describes a system for chronic stimulation and recording of thalamic-hippocampal theta activities in humans during memory tasks, showing their correlation with memory performance and modulation by deep brain stimulation.

Typical somatomotor physiology of the hand is preserved in a patient with an amputated arm

The paper investigates motor cortex electrophysiology in an amputee, finding preserved hand representations and high decoding accuracy for finger movements.