The paper develops and validates an open-source ecosystem for implantable brain-computer interfaces and adaptive neuromodulation, demonstrating its capabilities through preclinical and human studies.

bioRxiv · Aug 28, 2026 · PreprintBioengineering

Kainic Acid Pig Model of Hippocampal Epilepsy

Filip Mívalt, Daniela D. Maltais, Inyong Kim, Jiwon Kim, Patrik Began, Andrea Duque-Lopez, Veronika Krakorova, Bailey Winter, Cheng Yen Kuo, Shelja Sharma, Elizabeth S. Harty, Luke H. Kim, Nicholas Miller Gregg, Dan Montonye, Christopher K. Gow, , Gregory A. Worrell

This paper develops a porcine model of mesial temporal lobe epilepsy using kainic acid and an implantable device to study seizures and electrophysiological features.

Scientific Reports · Jun 4, 2026Peer-reviewedNeuroscience

Exploring GPCR-mediated optogenetic modulation of seizure network in a pig model of Temporal Lobe Epilepsy

Su-Youne Chang, Karni Lev Bar-Or, Filip Mívalt, Daniela D. Maltais, Yoav Kfir, Jiwon W. Kim, Inyong Kim, Matan Hershko, Jenn Daily, Evyatar Swissa, Ofir Levi, Sasha Devore, Ofer Yizhar, Yotam Eldar, Gregory A. Worrell

This study evaluates eOPN3, a red-shifted inhibitory opsin, in a pig model of Temporal Lobe Epilepsy to modulate seizure activity using optogenetics.

bioRxiv · Jan 23, 2025 · PreprintNeuroscience

Bred for affection: The canine anterior ectosylvian gyrus responds selectively to social reinforcement

Kai Joshua Miller, Frederik Lampert, Filip Mívalt, Inyong Kim, Nuri F. Ince, Jiwon W. Kim, Václav Křemen, Matthew R. Baker, M. A. Van den Boom, Dora Hermes, Volker Arnd Coenen, Gerwin Schalk, Peter Brunner, Gregory A. Worrell

The paper implants a neuromodulation platform in a beagle to study brain activity, finding the anterior ectosylvian gyrus responds selectively to social reinforcement, suggesting speech understanding may evolve from social brain structures.

bioRxiv · Jun 10, 2024 · PreprintAnimal Behavior & Cognition