Cryo-EM provides insight into how the Staphylococcus aureus IsdH receptor removes hemin from the hemoglobin:haptoglobin complex
Jess Soule, Brendan J. Mahoney, Andrew K. Goring, Joseph A. Loo, José A. Rodríguez, Robert Clubb
This paper uses cryo-EM to show how the Staphylococcus aureus IsdH receptor extracts hemin from the hemoglobin:haptoglobin complex by selectively engaging βHb and using N-linked glycans on haptoglobin to facilitate this process.
bioRxiv · Jun 8, 2026 · PreprintMicrobiology