Joseph A. Loo

This study benchmarks sub-50 nm quartz nanopipette emitters for native electrospray ionization mass spectrometry across multiple platforms and protein sizes, showing improved signal-to-noise and reduced adduction.

This paper uses cryo-EM to show how the Staphylococcus aureus IsdH receptor extracts hemin from the hemoglobin:haptoglobin complex by selectively engaging βHb and using N-linked glycans on haptoglobin to facilitate this process.

The paper uses visual proteomics to identify functional spirosomes in Clostridium thermocellum during biomass degradation.

This study identifies novel GFAP breakdown products and modifications in TBI patients, linking them to astrocyte pathology and clinical outcomes.

This study introduces ProteoMIX, a native top-down proteomics method to identify hemophores in C. diphtheriae, revealing protease-mediated release of soluble heme-binding proteoforms.

This study shows that CLR01, a supramolecular tweezer, reduces Atx3 aggregation by binding to a specific site, delaying fibril formation and improving symptoms in SCA3 models.

This paper shows PCMTD1, a cullin-RING ligase, recognizes L-isoaspartyl residues and targets damaged proteins for ubiquitylation and degradation.

This paper develops a method to label alpha synuclein fibrils with fluorophores for tracking their structure and function in cells.

This paper combines MicroED and native mass spectrometry to determine structures of enzyme-inhibitor complexes and identify high-affinity ligands from crude samples.

This study identifies iron-dependent changes in the exoproteome and surfaceome of C. diphtheriae 1737, revealing virulence factors involved in heme acquisition and host interaction.

The paper identifies TMEM106B, not TDP-43, as the protein composing amyloid fibrils in FTLD-TDP using cryo-EM.