MICROGLIAL EXTRACELLULAR VESICLES MEDIATE C1Q DEPOSITION AT THE PRE-SYNAPSE AND PROMOTE SYNAPTIC PRUNING
Giulia D’Arrigo, Giulia Cutugno, Maria Teresa Golia, Francesca M. Sironi, Marta Lombardi, Sara Francesca Colombo, Roberto Frigerio, Marina Cretich, Paola Gagni, Elisabetta Battocchio, Cristiana Barone, Emanuele Azzoni, Sonia Bellini, Claudia Saraceno, Roberta Ghidoni, , Claudia Verderio
This study shows that microglial extracellular vesicles deliver C1q to presynaptic sites, promoting synaptic pruning and linking vesicle release to synaptic remodeling.
Journal of Extracellular Vesicles · Dec 1, 2025Peer-reviewedNeuroscience