Author

Manuela Rizzi

Simons Initiative for the Developing BrainORCID 0000-0002-6174-7111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Emily K. OsterweiliD· 3 shared Aditi SinghiD· 1 shared Alex von KriegsheimiD· 1 shared Catherine M. AbbottiD· 1 shared Cavan Bennett-NessiD· 1 shared Danai KatsanevakiiD· 1 shared Grant F. MarshalliD· 1 shared Heather LoveiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Emily K. OsterweilORCID

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3 papers

Recent·Most cited

The most common epilepsy-causing mutation in EEF1A2 (E122K) perturbs the translation of specific transcripts but not the rate of global protein synthesis

Cavan Bennett-Ness, Manuela Rizzi, Heather Love, Nika Balkic, Grant F. Marshall, Alex von Kriegsheim, Emily K. Osterweil, Catherine M. Abbott

The paper investigates the E122K mutation in EEF1A2, showing it affects specific transcript translation but not global protein synthesis rate in neurons.

bioRxiv · Jul 11, 2026 · PreprintNeuroscience

Syngap+/- CA1 pyramidal neurons exhibit upregulated translation of long mRNAs associated with LTP

Aditi Singh, Manuela Rizzi, Sang S. Seo, Emily K. Osterweil

The paper identifies mistranslated long mRNAs in Syngap+/- CA1 neurons linked to LTP deficits, showing distinct translation changes compared to Fmr1-/y model.

eNeuro · Apr 28, 2025Peer-reviewedNeuroscience

Sex-specific resilience of neocortex to food restriction

Zahid Padamsey, Danai Katsanevaki, Patricia A. Maeso, Manuela Rizzi, Emily K. Osterweil, Nathalie L. Rochefort

This study shows that female mice's neocortex is more resilient to food restriction than males, with males showing changes in energy-regulating pathways and ATP usage.

eLife · Dec 15, 2023Peer-reviewedNeuroscience