Author

Aditi Singh

Boston Children's HospitalORCID 0009-0004-9209-8187Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Emily K. OsterweiliD· 3 shared Beatriz MaioiD· 2 shared Alexander RotenbergiD· 1 shared Brielle R. FergusoniD· 1 shared Catalina MartíneziD· 1 shared Elijah Hammarlund· 1 shared Francesca AriaiD· 1 shared Hart G.W. LidoviD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Emily K. OsterweilORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 16, 2026

FMR1 gene therapy restores activity-driven inhibition and prevents audiogenic seizures in Fmr1-/y mice

Beatriz Maio, Aditi Singh, Ralph Hector…·Emily K. Osterweil

This study shows that AAV-FMR1 gene therapy restores auditory circuit function and prevents audiogenic seizures in Fmr1-/y mice by normalizing translation and excitatory/inhibitory balance in the inferior colliculus.

DOI 10.64898/2026.06.12.731901

mouseexperimental assay

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NeurosciencebioRxivPreprintMar 12, 2026

FMR1 reduction alters cellular and circuit properties in human cortex

Aditi Singh, Saman Abbaspoor, Leeyup Chung…·Emily K. Osterweil

This study reduces FMR1 expression in human cortical slices to model Fragile X syndrome, revealing cell type-specific transcriptomic and electrophysiological changes not observed in mouse models.

DOI 10.64898/2026.03.11.711123

humanelectronic health records

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NeuroscienceeNeuroPeer-reviewedApr 28, 2025

Syngap+/- CA1 pyramidal neurons exhibit upregulated translation of long mRNAs associated with LTP

Aditi Singh, Manuela Rizzi, Sang S. Seo, Emily K. Osterweil

The paper identifies mistranslated long mRNAs in Syngap+/- CA1 neurons linked to LTP deficits, showing distinct translation changes compared to Fmr1-/y model.

2 citations

mouseproteomics

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