Rachael A. Wyatt

The paper identifies two regions in the CaSR cytoplasmic domain critical for β-arrestin recruitment, desensitization, and internalization, and shows mutations in these regions contribute to hypocalcemia.

This study identifies shared molecular mechanisms by which MRAP2 regulates GPCR signaling and shows that obesity-associated variants disrupt these mechanisms.

This study shows MRAP2 interacts with MC3R to enhance its signaling, affecting energy homeostasis and obesity risk.

This study shows GPR35 agonists reduce osteoclast activity in human cells by inhibiting bone resorption pathways, with effects comparable to existing osteoporosis drugs.

The paper uses high-content imaging to identify anti-resorptive GPCRs in human osteoclasts, finding four receptors that reduce osteoclast activity.

This study shows that obesity-associated MRAP2 variants impair multiple MC4R signaling pathways, including cAMP and IP3 signaling, and affect internalization.