Andrew M. James Shapiro

The paper examines islet isolation and culture outcomes at the Alberta Diabetes Institute IsletCore, finding islet loss occurs within 24 hours of isolation with no further loss after extended culture.

The paper shows that AT7867 increases pancreatic progenitor cell differentiation and accelerates diabetes reversal in mice.

The paper constructs a human DNA methylation atlas using whole-genome bisulfite sequencing of 39 cell types, revealing cell type-specific methylation patterns and regulatory elements.

This study identifies miR-125b-5p as a glucose-regulated miRNA that negatively regulates β-cell function by modulating organelle dynamics and insulin secretion.

This study identifies miR-7-mediated repression of Brg1 as a driver of β-cell dedifferentiation through EMT, leading to fibrosis and impaired glucose tolerance in diabetes.

The paper develops a method to determine the tissue origins of circulating cell-free DNA using a methylation atlas and validates it in healthy and disease states.