Genetic & Genomic MedicineScientific ReportsPeer-reviewed
Progression GWAS followed by functional characterization implicates E3 ubiquitin ligase TRIM2 as a potential genetic modifier of Parkinson's Disease progression
Ameya S Kulkarni, Daniel J. Apicco, Saleh Tamim…·Hyun Ji Noh
The paper performs a GWAS on PD progression metrics and identifies TRIM2 as a genetic modifier, showing its role in regulating neurofilament light and alpha-synuclein aggregation.
DOI 10.1038/s41598-026-67630-7