Progression GWAS followed by functional characterization implicates E3 ubiquitin ligase TRIM2 as a potential genetic modifier of Parkinson's Disease progression
Ameya S Kulkarni, Daniel J. Apicco, Saleh Tamim, Lauren Gibilisco, Layan Nahlawi, Rachel McFarland Lucia, Sujana Ghosh, Samantha Lent, Yanyu Liang, Saurabh Khasnavis, LAURA B. SMITH, Joshua D. Stender, Priyanka Vijay, Cindy Zadikoff, J. Wade Davis, , Hyun Ji Noh
The paper performs a GWAS on PD progression metrics and identifies TRIM2 as a genetic modifier, showing its role in regulating neurofilament light and alpha-synuclein aggregation.
Scientific Reports · Sep 2, 2026Peer-reviewedGenetic & Genomic Medicine