J. Wade Davis

A Turing-Style Test for In-Silico Antibodies: How Sampling Mode Makes WGAN-GP Beat VAE in the Wet Lab

This paper compares GANs and VAEs for generating viable antibody sequences, finding GANs outperform VAEs when sampling strategies are optimized.

Progression GWAS followed by functional characterization implicates E3 ubiquitin ligase TRIM2 as a potential genetic modifier of Parkinson's Disease progression

The paper performs a GWAS on PD progression metrics and identifies TRIM2 as a genetic modifier, showing its role in regulating neurofilament light and alpha-synuclein aggregation.

Fine scale structural information substantially improves multivariate regression model for mRNA in-vial degradation prediction

This paper improves mRNA stability prediction by incorporating fine-scale structural metrics into a regression model, achieving better accuracy than existing methods.

mRNAfold: Co-optimization of Global Stability, Local Structure, and Codon Choice via Suboptimal Folding

mRNAfold improves mRNA design by co-optimizing stability, local structure, and codon choice, showing better in-solution stability and complex effects on protein production.

Systematic single-variant and gene-based association testing of thousands of phenotypes in 426,370 UK Biobank exomes

The paper performs single-variant and gene-based association analyses of 4,529 phenotypes using exome data from 426,370 UK Biobank individuals, finding associations linked to variant frequency and deleteriousness.

Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank

The paper describes exome sequencing of 200,643 UK Biobank participants, providing a rich resource of coding variants for genetic and drug discovery research.

Estimating colocalization probability from limited summary statistics

The paper introduces POEMColoc, a method to estimate colocalization probability using limited summary statistics, and finds evidence for colocalization between 150,000 trait-gene-tissue triplets.

The SEQC2 Epigenomics Quality Control (EpiQC) Study: Comprehensive Characterization of Epigenetic Methods, Reproducibility, and Quantification

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

This paper performs a large-scale eQTL meta-analysis across cerebral cortical and cerebellar brain regions, identifying distinct eQTL patterns and demonstrating improved power over existing studies.

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval.

Updated pipeline and genetic data confirm genetically supported drug targets succeed more often; Mendelian (OMIM) support replicates prospectively, while GWAS support is weaker unless coding-linked.