Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
Vincent Quoc‐Huy Trinh, Katherine E. Ankenbauer, Sabrina M. Torbit, Jiayue Liu, Maëlle Batardière, Bhoj Kumar, H. Carlo Maurer, Frank L. Revetta, Zhengyi Chen, Angela R.S. Kruse, Audra M. Judd, Celina Copeland, Jahg Wong, Olivia Ben‐Levy, Brenda Jarvis, , Kathleen E. DelGiorno
This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.
bioRxiv · Feb 25, 2024 · PreprintCancer Biology