Author

Frank L. Revetta

Vanderbilt University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

Alan J. SimmonsiD· 4 shared Ken S. LauiD· 4 shared Marisol A Ramirez-SolanoiD· 4 shared Harsimran KauriD· 3 shared Naila TasneemiD· 3 shared Nicholas O. MarkhamiD· 3 shared Robert J. CoffeyiD· 3 shared Cynthia L. SearsiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Alan J. SimmonsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatial atlas highlights contribution of C. difficile in early-stage colorectal cancer

Nicholas O. Markham, Julia L. Drewes, Emily H. Green, William Ball, Hannah M. Lunnemann, Alan J. Simmons, Harsimran Kaur, Jessica Queen, Abby L. Geis, Maryam Pourmaleki, Bryan R. Helm, Erik P. Storrs, Marisol A Ramirez-Solano, Xiang Li, Zhicheng Ma, , Robert J. Coffey

The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.

bioRxiv · Jun 20, 2026 · PreprintCancer Biology

Unbiased recording of clonal potency reveals species-specific regulation of mammalian intestine

Mirazul Islam, Matthew E. Bechard, Yilin Yang, Alan J. Simmons, Yanwen Xu, James N. Higginbotham, Ping Zhao, Zheng Cao, Naila Tasneem, Sarah E. Glass, Nicholas O. Markham, Frank L. Revetta, Marisol A Ramirez-Solano, Qi Liu, Jeffrey L. Franklin, , Robert J. Coffey

The paper uses clonal analysis to reveal species-specific differences in intestinal regeneration and stem cell dynamics in mice and humans.

bioRxiv · Jun 10, 2025 · PreprintGenomics

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn's Disease

Jia Li, Alan J. Simmons, Caroline V. Hawkins, Sophie Chiron, Marisol A Ramirez-Solano, Naila Tasneem, Harsimran Kaur, Yanwen Xu, Frank L. Revetta, Paige N. Vega, Shunxing Bao, Can Cui, Regina N. Tyree, Larry W. Raber, Anna N. Conner, , Qi Liu

The paper identifies a novel epithelial cell type, LND, in Crohn's disease that is associated with immune dysregulation and disease activity.

Nature Communications · Aug 22, 2024Peer-reviewedBioinformatics

Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors

Cody N. Heiser, Alan J. Simmons, Frank L. Revetta, Eliot T. McKinley, Marisol A Ramirez-Solano, Jiawei Wang, Harsimran Kaur, Justin Shao, Gregory Daniel Ayers, Yu Wang, Sarah E. Glass, Naila Tasneem, Zhengyi Chen, Yan Qin, William Kim, , Ken S. Lau

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.

Cell · Dec 1, 2023Peer-reviewedSystems Biology