H. Carlo Maurer

Modeling pancreatic cancer tumor stroma co-evolution in an in ovo model

This study uses an in ovo model to show that the CAM platform supports tumor-stroma coevolution in pancreatic cancer, preserving patient-specific features and enabling functional analysis of stromal interactions.

PHGDH is a targetable driver of PDAC progression

This study identifies PHGDH as a driver of PDAC progression by maintaining glutamine metabolism and mTOR signaling, revealing a therapeutic vulnerability to glutamine antagonism in PHGDH-deficient tumors.

Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinoma

This study identifies LINC00673, a long noncoding RNA from a Sox9-associated super-enhancer, as critical for pancreatic regeneration and PDAC initiation by regulating cell-autonomous and non-cell-autonomous processes.

Transcriptional deconvolution reveals consistent functional subtypes of pancreatic cancer epithelium and stroma

The paper develops an algorithm to deconvolve bulk tumor gene expression data and identifies consistent functional subtypes in pancreatic cancer epithelium and stroma.