Vincent Quoc‐Huy Trinh

Tumour-stroma signaling drives a reversible program with neural-like features in cancer-associated fibroblasts

The paper identifies tumor-derived signals that induce a reversible neural-like program in cancer-associated fibroblasts and shows it is regulated by growth factors and MAPK/ERK signaling.

Spatial multi-omics resolve epithelium-fibroblast gradients and highlight NESTIN-NOTCH1-expressing subepithelial fibroblasts during human pancreatic tumorigenesis

This study uses spatial multi-omics to identify NESTIN-NOTCH1-expressing fibroblasts in IPMNs and their role in pancreatic tumorigenesis.

Spatial analysis of Intraductal Papillary Mucinous Neoplasms reveals secretory cell-enriched neighborhoods

The paper uses spatial transcriptomics and immunostaining to analyze secretory cell distribution in IPMNs, finding spatial enrichment of specific cell types and associations with immune and fibroblast populations.

Early IKKb-dependent anabolic signature governs vascular smooth muscle cells fate and abdominal aortic aneurysm development

This study identifies an early IKKβ-dependent anabolic signature in vascular smooth muscle cells that drives abdominal aortic aneurysm development.

Lipid-based nanoparticles deliver mRNA to reverse the pathogenesis of lysosomal acid lipase deficiency in a preclinical model

Screening of a mRNA-LNPs library yielded a formulation with outmost potency and mitigated the progression of LAL deficiency in a preclinical model.

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.