Combination of Imipridone ONC201 or ONC206 with Temozolomide and Radiotherapy in triple ITR therapy reduces intracranial tumor burden and prolongs survival in an orthotopic wild-type IDH GBM mouse model
Lanlan Zhou, Leiqing Zhang, Jun Zhang, Laura Jinxuan Wu, Shengliang Zhang, Andrew George, Marina Hahn, Howard P. Safran, Clark C. Chen, Attila A. Seyhan, Eric T. Wong, Wafik S. El‐Deiry
This paper shows that combining ONC201 or ONC206 with temozolomide and radiotherapy significantly extends survival in a GBM mouse model compared to single treatments.
Oncotarget · Mar 27, 2025Peer-reviewedCancer Biology