Clark C. Chen

This study shows TTFields increase p21 expression and induce cell death in TNBC cells, with enhanced effects when combined with talazoparib.

This study identifies a SRC-Annexin A2 axis that links membrane repair to microRNA export during radiation stress in glioblastoma, enhancing radiation resistance.

This paper demonstrates that combining oncolytic adenovirus encoding bispecific T cell engager (OV-BiTE) with CAR-T cells enhances T cell recruitment and tumor eradication in glioblastoma xenograft models.

The paper shows that miR-181d degradation via a PNPT1-ATR feed-forward loop increases MGMT expression variance, leading to temozolomide resistance in glioblastoma cells.

This paper shows that combining ONC201 or ONC206 with temozolomide and radiotherapy significantly extends survival in a GBM mouse model compared to single treatments.

The paper identifies sex differences in microglial inflammatory responses in glioblastoma, showing that genes on the inactive X chromosome drive these differences.

The paper introduces Droplet Hi-C, a method for single-cell chromatin conformation profiling, and demonstrates its application in analyzing gene regulatory programs and detecting genetic variations in cancer cells.

This study develops human iPSC-derived tumor models to investigate the cooperative effects of H3.3K27M and PDGFRA mutations in DMG, identifying therapeutic vulnerabilities.

This study uses calcium imaging to show that repetitive mild traumatic brain injury in mice causes long-term changes in cortical functional connectivity without affecting cognitive or motor function.