Author

Daniel T. Montoro

Broad InstituteORCID 0000-0002-6222-2149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 3 Organism:human· 3 Approach:machine learning (classical)· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Karthik A. JagadeeshiD· 3 shared Alkes L. PriceiD· 2 shared Avinash WaghrayiD· 2 shared Ayshwarya SubramanianiD· 2 shared Christoph MuusiD· 2 shared Graham HeimbergiD· 2 shared J EngreitziD· 2 shared Joshua GouldiD· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Karthik A. JagadeeshORCID

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3 papers

Recent·Most cited

Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human genetics

Karthik A. Jagadeesh, Kushal K. Dey, Daniel T. Montoro, Rahul R. Mohan, Steven Gazal, J Engreitz, Ramnik J. Xavier, Alkes L. Price, Aviv Regev

The paper integrates single-cell RNA-seq, epigenomic maps, and GWAS data to identify disease-critical cell types and processes across multiple diseases and tissues.

bioRxiv · Mar 19, 2021 · PreprintGenomics

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Toni Marie Delorey, Carly G.K. Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Åsa Segerstolpe, Domenic Abbondanza, Stephen J. Fleming, Ayshwarya Subramanian, Daniel T. Montoro, Karthik A. Jagadeesh, Kushal K. Dey, Pritha Sen, Michal Slyper, Yered H. Pita-Juárez, , Alexandra–Chloé Villani

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

bioRxiv · Feb 25, 2021 · PreprintGenomics

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Christoph Muus, Malte D. Luecken, Gökçen Eraslan, Avinash Waghray, Graham Heimberg, Lisa Sikkema, Yoshihiko Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya Subramanian, Christopher Smilie, Karthik A. Jagadeesh, Thu Elizabeth Duong, Evgenij Fiškin, Elena Torlai Triglia, Meshal Ansari, , Wenjun Yan

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.

bioRxiv · Apr 19, 2020 · PreprintBioinformatics✦ In-depth digest