Joshua A. Shapiro

The paper provides a uniformly processed compendium of alternative splicing profiles from pediatric cancer and non-diseased tissues, enabling large-scale analysis of splicing aberrations in pediatric cancers.

The paper introduces a data portal and open-source tools for single-cell transcriptomics of pediatric tumors, providing uniformly processed RNA-seq data and metadata from over 700 samples across 55 cancer types.

OpenPBTA provides a collaborative platform to genomically characterize 1,074 pediatric brain tumors and 22 cell lines, offering analysis modules and somatic datasets for research and clinical applications.