Author

John W. Cuozzo

Relay Therapeutics (United States)ORCID 0000-0002-6229-0395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:machine learning (classical)· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Aiping DongiD· 2 shared Albina Bolotokova· 2 shared Anthony D. KeefeiD· 2 shared Ashley HutchinsoniD· 2 shared Hong ZengiD· 2 shared Jianwen A. FengiD· 2 shared John P. Guilinger· 2 shared Levon HalabelianiD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Aiping DongORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Medicinal ChemistryPeer-reviewedNov 4, 2024

A resource to enable chemical biology and drug discovery of WDR Proteins

Suzanne Z. Ackloo, Fengling Li, Magda Szewczyk…·C. H. Arrowsmith

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

28 citations

humanprotein structure

𝕏 PostBluesky

Molecular BiologyJournal of Medicinal ChemistryPeer-reviewedNov 23, 2023

Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

Shabbir Ahmad, Jin Bao Xu, Jianwen A. Feng…·Levon Halabelian

The paper identifies a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection and machine learning, leading to the discovery of covalent analogs and structural insights.

22 citations

machine learning (classical)drug response / drug discovery

𝕏 PostBluesky