Deborah E. Cabin

The paper measures PrP half-life in vivo and shows it limits the time to effect of PrP-lowering therapies, with implications for drug development and clinical trial design.

This study identifies Snca as a genetic modifier of Atp7a in female mice, revealing a potential role for Snca in the ER-Golgi system in a sex-dependent manner.

This study tests anle138b in mouse models of prion disease, finding improved survival in RML strain models but no clear endpoints in genetic mutation models.

This study shows that lowering prion protein expression with ASOs is effective in treating prion disease across different strains, treatment times, and endpoints.