Author

Gowthami Mahendran

Indiana University IndianapolisORCID 0000-0002-6264-4501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:rat· 1

Frequent Co-Authors

Bonnie L. Blazer‐YostiD· 2 shared David AuduiD· 2 shared Bonnie Blazer-Yost· 1 shared Fatemeh Omidi BidgoliiD· 1 shared Lauren Jantzie· 1 shared Maryam TorabiiD· 1 shared Piriyankan KirupaharaniD· 1 shared Robinson Shenandoah· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Bonnie L. Blazer‐YostORCID

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3 papers

Recent·Most cited

Therapeutic Potential of Melatonin, Erythropoietin, and TRPV4 Antagonism in a Preclinical Model of Genetic Hydrocephalus

Fatemeh Omidi Bidgoli, David Audu, Gowthami Mahendran, Yanping Zhang, Lauren Jantzie, Robinson Shenandoah, Bonnie Blazer-Yost

This study evaluates a triple therapy of erythropoietin, melatonin, and TRPV4 antagonist in a rat model of congenital hydrocephalus, showing reduced ventricular expansion and inflammation.

bioRxiv · Nov 6, 2026 · PreprintNeuroscience

Use of Integrative Proteomic Analysis to Uncover Shared Molecular Signatures Across Distinct Forms of Hydrocephalus

Gowthami Mahendran, Piriyankan Kirupaharan, David Audu, Bonnie L Blazer-Yost

This study identifies shared and etiology-specific proteomic signatures across hydrocephalus subtypes using cross-study proteomic analysis of CSF.

bioRxiv · Nov 5, 2026 · PreprintNeuroscience

Phosphoproteomic Insights into TRPV4 - AMPK Signaling Axis in the Choroid Plexus Epithelium: Implications for Therapeutic Targeting in Hydrocephalus

Gowthami Mahendran, Maryam Torabi, Bonnie L. Blazer‐Yost

The paper investigates the TRPV4-AMPK signaling axis in choroid plexus epithelial cells using phosphoproteomics, showing that AMPK inhibition enhances barrier tightness and suggests metformin as a potential therapeutic agent for hydrocephalus.

bioRxiv · Jul 18, 2026 · PreprintNeuroscience