BiophysicsbioRxivPreprint
Expansion of DNA-Encoded Library Hits Using Generative Chemistry and Ultra-Large Compound Catalogs
Brandon Novy, Shu-Hang Lin, Devan J. Shell…·Konstantin I. Popov
This paper combines DNA-encoded libraries with generative AI to expand hit compounds, finding AI-selected hits show better drug-likeness and diversity than initial DEL hits.
DOI 10.1101/2025.09.30.679600