Devan J. Shell

DELi is an open-source platform for DNA-encoded library design, decoding, and analysis, demonstrating its effectiveness through the identification of a BRD4 binder.

This paper combines DNA-encoded libraries with generative AI to expand hit compounds, finding AI-selected hits show better drug-likeness and diversity than initial DEL hits.

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

The paper shows that (R,R)-59, a SETDB1 ligand, enhances SETDB1-mediated methylation of Akt1 and promotes cell proliferation.