Chizuru Kinoshita

This study develops 2D and 3D human in vitro neurovascular unit models to investigate microglial interactions with endothelial cells and their role in neurovascular function under inflammatory conditions.

This study shows that SORL1 deficiency in human microglia leads to lysosomal dysfunction, including impaired degradation and enzyme activity, contributing to Alzheimer's disease pathogenesis.

The paper tests if a retromer stabilizing drug, TPT-260, can correct endosomal and Alzheimer's-related pathologies in neurons with SORL1 variants.

The paper compiles an annotated set of 171 small molecule modulators targeting 98 novel AD therapeutic proteins, serving as chemical tools for hypothesis validation.

This study shows that reducing HDAC2 in hiPSC-derived neurons enhances mitochondrial function and reduces neurotoxic amyloid beta, suggesting HDAC2's role in neuronal maturation and disease.