Kenneth H. Pearce

DELi is an open-source platform for DNA-encoded library design, decoding, and analysis, demonstrating its effectiveness through the identification of a BRD4 binder.

This study identifies a host-directed adjuvant, KL1, that increases intracellular bacterial energy and sensitizes persisters to antibiotics by modulating host immune responses and reducing reactive species production.

This paper combines DNA-encoded libraries with generative AI to expand hit compounds, finding AI-selected hits show better drug-likeness and diversity than initial DEL hits.

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

The paper identifies inhibitors of Chikungunya virus nsP2 ATPase by screening compounds that reduce ATP hydrolysis.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

The paper identifies potent covalent inhibitors of Chikungunya nsP2 protease and establishes structure-activity relationships to guide inhibitor design.

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

This study identifies MSN and CD44 as potential therapeutic targets for Alzheimer's disease by developing inhibitors of their interaction through structural and chemical screening.

The paper shows that (R,R)-59, a SETDB1 ligand, enhances SETDB1-mediated methylation of Akt1 and promotes cell proliferation.

The paper compiles an annotated set of 171 small molecule modulators targeting 98 novel AD therapeutic proteins, serving as chemical tools for hypothesis validation.