Richard R. Drake

The paper uses spatial glycomics to show that N-glycan abnormalities in MOGHE are linked to hypomyelination and are more pronounced in pediatric cases.

The paper identifies ECM proteomic signatures associated with disease-free survival in DCIS and IBC, showing reduced collagen peptides correlate with poorer outcomes.

This paper maps mucin glycoforms in tumors using on-tissue digestion and mass spectrometry, revealing distinct glycosylation patterns in colorectal mucinous adenocarcinomas.

This paper introduces a method using post-glycosylation modifying enzymes to visualize specific PGMs in tissue N-glycans via mass spectrometry imaging.

This study analyzes multi-omic data from gliomas to identify therapeutic escape mechanisms and TME evolution, finding that N-glycosylation classifies tumor grade and immune transcriptome predicts GBM survival.

This study identifies sialic acid linkage profiles in liver cancers to differentiate between cholangiocarcinoma subtypes and hepatocellular carcinoma.

This study identifies hypersialylation in intervertebral disc degeneration and shows it modulates inflammation and metabolism.

This study uses cortical organoids to show that ALG13 loss-of-function causes glycosylation defects, neuronal maturation issues, and network hypoactivity in CDG.

This study analyzes the spatial collagen proteome in normal breast tissue, linking it to BI-RADS categories and BMI through proteomic and imaging analyses.

The paper characterizes changes in N-glycosylation and related molecular signatures in the Parkinsonian human nigro-striatal region, linking them to endoplasmic reticulum stress and potential therapeutic implications.