Jade K. Macdonald

The paper develops an optimized multimodal imaging workflow that preserves tissue integrity and enables comprehensive profiling of morphology, collagen, cell populations, N-glycans, and extracellular matrix peptides from a single tissue section.

The paper identifies ECM proteomic signatures associated with disease-free survival in DCIS and IBC, showing reduced collagen peptides correlate with poorer outcomes.

This study analyzes the spatial collagen proteome in normal breast tissue, linking it to BI-RADS categories and BMI through proteomic and imaging analyses.