Author

Takahiro Kosugi

National Institutes of Natural SciencesORCID 0000-0002-6289-5319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Organism:yeast· 1

Frequent Co-Authors

Akira YamashitaiD· 1 shared Chiharu Umeda· 1 shared Hokuto OhtsukaiD· 1 shared Mikio TanabeiD· 1 shared Nobuyasu KogaiD· 1 shared Yoko OtsuboiD· 1 shared Yoshiaki KamadaiD· 1 shared Yukio MukaiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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1 shared paperMolecular Biology

Akira YamashitaORCID

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2 papers

Recent·Most cited

BiophysicsProtein SciencePeer-reviewedMay 13, 2025

De novo design of ATPase based on the blueprint optimized for harboring the P-loop motif

Takahiro Kosugi, Mikio Tanabe, Nobuyasu Koga

This paper designs a de novo ATPase with a P-loop motif, showing high thermal stability and ATPase activity, but not matching natural enzymes' efficiency.

DOI 10.1002/pro.70132

protein structuredeep learning

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Molecular BiologyJournal of Cell SciencePeer-reviewedFeb 15, 2024

Structure-based engineering of Tor complexes uncovers different roles of two types of yeast TORC1s

Yoshiaki Kamada, Chiharu Umeda, Yukio Mukai…·Takahiro Kosugi

The paper engineers yeast TORC1 complexes to reveal distinct functional roles of Tor1- and Tor2-containing TORC1s in growth and lifespan.

5 citations

yeastexperimental assay

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