Jerome S. Bignon

The knockdown of the snoRNA-jouvence blocks the cell proliferation and leads to cell death of human primary cancerous glioblastoma cells

This study shows that knocking down snoRNA-jouvence in human glioblastoma cells reduces proliferation and induces apoptosis, suggesting it as a potential therapeutic target.

Neural crest mural cells of forebrain meninges harbor innate immune functions during early brain development and exhibit different responses to septic and toxic insults

This study identifies CNC mural cells as innate immune cells in the developing forebrain, showing their phagocytic and antigen-presenting capabilities and responses to bacterial and toxic insults.

jouvence, a new human H/ACA snoRNA involves in the control of cell proliferation and differentiation

This study characterizes a new human H/ACA snoRNA, jouvence, showing it promotes cell proliferation and dedifferentiation while its knockdown reduces proliferation and ribosome biogenesis.