Zhuo Du

Discovery of Waddington's developmental canals elucidates the embryogenesis stability in Caenorhabditis elegans

This study identifies and quantifies developmental canals in C. elegans embryogenesis that suppress noise and stabilize development, revealing how cell-level stochasticity affects phenotypic outcomes.

Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo

The paper identifies 119 cell-states in C. elegans embryos during early development, revealing lineage-specific gene regulatory programs that encode cell position and fate.

Single-cell Protein Atlas of Transcription Factors Reveals the Combinatorial Code for Spatiotemporal Patterning the C. elegans Embryo

The paper constructs a single-cell protein atlas of 266 transcription factors in C. elegans embryos, revealing combinatorial regulatory codes and lineage-specific functions in spatiotemporal patterning.

Multidimensional Chromatin Regulation of Cell Lineage Differentiation in a Metazoan Embryo

The paper maps chromatin activity during C. elegans embryogenesis to understand how chromatin regulation influences cell lineage differentiation and tissue-specific states.

Multivariable regulation of gene expression plasticity in metazoans

This study quantifies gene expression plasticity across four metazoan species, identifies conserved regulatory elements, and links plasticity to gene function and disease.

Deterministic Nature of Cellular Position Noise During C. elegans Embryogenesis

The paper quantifies and shows that cellular position noise during C. elegans embryogenesis is deterministic and regulated by lineage and developmental factors.