Single-cell phylodynamic inference of tissue development and tumor evolution with scPhyloX
Kun Wang, Zhaolian Lu, Zeqi Yao, Xionglei He, Zheng Hu, Da Zhou
scPhyloX infers tissue development and tumor evolution dynamics using single-cell phylogenetic trees, revealing novel insights into stem cell overshoot, hematopoietic progenitor clonal expansion, and colorectal tumor subclonal selection.
bioRxiv · May 15, 2024 · PreprintBioinformatics