Global Analysis by LC-MS/MS of N6-Methyladenosine and Inosine in mRNA Reveals Complex Incidence
Stanislav Stejskal, Veronika Rájecká, Helena Covelo Molares, Ketty Sinigaglia, Květoslava Brožinová, Linda Kasiarova, Michaela Dohnálková, Paul Eduardo Reyes‐Gutierrez, Hana Cahová, Liam P. Keegan, Mary A. O’Connell, Štěpánka Vaňáčová
This paper develops a method to detect and quantify mRNA modifications like m6A, m6Am, and m1A in human RNA, revealing FTO's role in m6Am and ALKBH5's effect on inosine levels.
RNA · Jan 2, 2025Peer-reviewedMolecular Biology