Kristofer C. Berrett

Genetic demultiplexing of pooled single-cell RNA-sequencing samples in cancer facilitates effective experimental design

The paper evaluates genetic demultiplexing tools for pooled single-cell RNA-seq in cancer, showing they work effectively despite challenges from ambient RNA.

Regulatory Sharing Between Estrogen Receptor α Bound Enhancers

The paper investigates how estrogen receptor α bound enhancers cooperate to regulate gene expression, finding that full ERE motifs and pre-existing chromatin states are critical for enhancer activity.

ETV4 is necessary for estrogen signaling and growth in endometrial cancer cells

This study shows ETV4 is essential for estrogen signaling and growth in endometrial cancer cells by enabling ER binding and nuclear translocation.

Sufficiency analysis of estrogen responsive enhancers using synthetic activators

This study tests the sufficiency of estrogen receptor-binding sites (ERBS) for activating gene expression using synthetic activators, finding that individual ERBS can act independently when directly recruited.