Matthew Ginley-Hidinger

The paper identifies estrogen-induced chromatin looping changes in endometrial cancer cells and shows their correlation with transcriptional responses, though not all loops are essential for estrogen regulation.

This study identifies cis-regulatory elements that control transcriptional timing and noise in response to estrogen using single-cell RNA-seq and machine learning.

The paper investigates how estrogen receptor α bound enhancers cooperate to regulate gene expression, finding that full ERE motifs and pre-existing chromatin states are critical for enhancer activity.

This study tests the sufficiency of estrogen receptor-binding sites (ERBS) for activating gene expression using synthetic activators, finding that individual ERBS can act independently when directly recruited.