Author

Hisaaki Shinohara

RIKEN Center for Integrative Medical SciencesORCID 0000-0002-6331-2138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Itoshi NikaidoiD· 1 shared Johannes Nicolaus WibisanaiD· 1 shared Kentaro InoueiD· 1 shared Mana UmedaiD· 1 shared Mariko OkadaiD· 1 shared Masashi EbisawaiD· 1 shared Noriko Yumoto· 1 shared Takehiko InabaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Itoshi NikaidoORCID

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2 papers

Recent·Most cited

Cellular inhibitor of apoptosis protein (cIAP) is a convergent hub that couples BCR-CD40 signal dynamics to B cell fate

Kentaro Inoue, Hisaaki Shinohara

The paper identifies cIAP as a hub that couples BCR and CD40 signaling to B cell fate by sustaining canonical NF-κB signaling and restraining non-canonical pathways.

bioRxiv · Aug 30, 2026 · PreprintImmunology

Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers

Johannes Nicolaus Wibisana, Takehiko Inaba, Hisaaki Shinohara, Noriko Yumoto, Tetsutaro Hayashi, Mana Umeda, Masashi Ebisawa, Itoshi Nikaido, Yasushi Sako, Mariko Okada

The paper investigates NF-κB super-enhancers in B cells, finding they enhance transcriptional variability and gene expression through cis-regulatory interactions and NF-κB binding sites.

PLoS Genetics · Jun 1, 2022Peer-reviewedMolecular Biology