Yasushi Sako

The paper studies the behavior of human RTKs using single-molecule imaging and finds that molecular behavior correlates with cell growth regulation.

This study shows that PI(4,5)P2 and ErbB2 levels regulate ErbB receptor oligomerization and kinase activity differently across family members.

This study uses transfer entropy to analyze information flow in the RAS-MAPK system, revealing bidirectional feedback and identifying functional disorder in a Noonan syndrome-associated SOS mutation.

This study uses super-resolution microscopy to show that EGFR and PI(4,5)P2 nanodomains coaggregate before EGF stimulation, and their interaction is regulated by phospholipase Cγ and PI(4,5)P2 levels.

The paper develops a four-color single-molecule imaging system using fluorescent HiBiT peptides to track GPCR dynamics and interactions in living cells.

The paper identifies potentially functional transposon-mobility genes in the C. elegans genome, finding that only a limited number of transposons are autonomously mobile.

The paper investigates NF-κB super-enhancers in B cells, finding they enhance transcriptional variability and gene expression through cis-regulatory interactions and NF-κB binding sites.

The paper investigates how differences in ERBB receptor expression and phosphorylation rates contribute to diverse phosphorylation dynamics across organs.

The paper quantifies Wnt8 ligand dynamics in Xenopus embryos, showing most Wnt8 is bound to cell surfaces with dynamic exchange, leading to a graded distribution.

The paper analyzes single-cell responses to growth factors using phosphorylation data to show cell-to-cell variation in signal transduction and suggests a bet-hedging strategy in fate decisions.