Author

Isabel Lam

Brigham and Women's HospitalORCID 0000-0002-6343-6966Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Scott KeeneyiD· 2 shared Hajime MurakamiiD· 1 shared Jacquelyn Song· 1 shared Megan van Overbeek· 1 shared Pei-Ching Huang· 1 shared

Activity by Year

2015-2020 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersGenetics

Scott KeeneyORCID

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2 papers

Recent·Most cited

GeneticsNaturePeer-reviewedMay 6, 2020

Multilayered mechanisms ensure that short chromosomes recombine in meiosis

Hajime Murakami, Isabel Lam, Pei-Ching Huang…·Scott Keeney

This study shows that Saccharomyces cerevisiae uses multiple mechanisms to control DSB formation on short chromosomes to prevent meiotic missegregation.

76 citations

yeastexperimental assay

𝕏 PostBluesky

Evolutionary BiologySciencePeer-reviewedNov 20, 2015

Non-paradoxical evolutionary stability of the recombination initiation landscape in Saccharomycetes

Isabel Lam, Scott Keeney

The paper compares meiotic recombination initiation maps across yeast species to test whether hotspot positions and strengths are conserved or ephemeral.

DOI 10.1126/science.aad0814

yeastDNA methylation

𝕏 PostBluesky