Author

Tobias Hegelund Olsen

University of OxfordORCID 0000-0002-6348-4650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:database / resource· 3 Approach:deep learning· 3 Assay:protein sequence· 3 Research Focus:sequence-to-function modeling· 3 Research Focus:benchmarking· 2 Assay:protein structure· 2 Research Focus:software / tool· 2 Approach:statistical model· 2

Frequent Co-Authors

Charlotte Mary DeaneiD· 5 shared Iain H. MoaliD· 3 shared Brennan AbanadesiD· 2 shared Broncio Aguilar-SanjuaniD· 2 shared Matthew I. J. RaybouldiD· 2 shared Alexander BujotzekiD· 1 shared Alexander Greenshields‐WatsoniD· 1 shared Alexandre M. J. J. BonviniD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersBioinformatics

Charlotte Mary DeaneORCID

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Author profile →

6 papers

Recent·Most cited

Addressing the antibody germline bias and its effect on language models for improved antibody design

Tobias Hegelund Olsen, Iain H. Moal, Charlotte Mary Deane

This study addresses germline bias in antibody language models by developing AbLang-2, which predicts non-germline residues more effectively than existing models.

Bioinformatics · Oct 23, 2024Peer-reviewedBioinformatics

The Observed T cell receptor Space database enables paired-chain repertoire mining, coherence analysis and language modelling

Matthew I. J. Raybould, Alexander Greenshields‐Watson, Parth Agarwal, Broncio Aguilar-Sanjuan, Tobias Hegelund Olsen, Oliver M. Turnbull, Nele P. Quast, Charlotte Mary Deane

The paper introduces the OTS database, a curated resource of paired-chain TCR sequences, and develops a language model for analyzing TCR pairings and coherence.

Cell Reports · Aug 29, 2024Peer-reviewedImmunology

The Patent and Literature Antibody Database (PLAbDab): an evolving reference set of functionally diverse, literature-annotated antibody sequences and structures

Brennan Abanades, Tobias Hegelund Olsen, Matthew I. J. Raybould, Broncio Aguilar-Sanjuan, Wing Ki Wong, Guy J. Georges, Alexander Bujotzek, Charlotte Mary Deane

PLAbDab is a database of over 150,000 antibody sequences and structures with literature annotations, enabling searches by sequence, structure, or keyword for functional insights.

Nucleic Acids Research · Oct 28, 2023Peer-reviewedBioinformatics

KA-Search: Rapid and exhaustive sequence identity search of known antibodies

Tobias Hegelund Olsen, Brennan Abanades, Iain H. Moal, Charlotte Mary Deane

KA-Search rapidly and exhaustively searches for similar antibody sequences across defined regions in large antibody repertoires to predict properties like immunogenicity and antigen specificity.

bioRxiv · Nov 1, 2022 · PreprintBioinformatics

AbLang: An antibody language model for completing antibody sequences

Tobias Hegelund Olsen, Iain H. Moal, Charlotte Mary Deane

AbLang is an antibody-specific language model that restores missing residues in antibody sequences more effectively than existing methods.

Bioinformatics Advances · Jan 1, 2022Peer-reviewedBioinformatics

proABC-2: PRediction Of AntiBody Contacts v2 and its application to information-driven docking

Francesco Ambrosetti, Tobias Hegelund Olsen, Pier Paolo Olimpieri, Brian Jiménez‐García, Edoardo Milanetti, Paolo Marcatili, Alexandre M. J. J. Bonvin

proABC-2 predicts antibody-antigen contacts using a convolutional neural network and integrates with HADDOCK for docking.

Bioinformatics · Jul 13, 2020Peer-reviewedBioinformatics