Guy J. Georges

The paper predicts the structural flexibility of antibody and T-cell receptor CDR3 loops using a new method trained on a large dataset of conformations.

PLAbDab is a database of over 150,000 antibody sequences and structures with literature annotations, enabling searches by sequence, structure, or keyword for functional insights.

SPACE2 improves epitope clustering by using structural models, showing higher coverage and diversity in antibodies binding the same epitope compared to sequence-based methods.

ImmuneBuilder predicts immune protein structures with high accuracy and speed, outperforming AlphaFold2 on specific benchmarks.

ABlooper predicts antibody CDR loop structures with high accuracy and confidence estimates, achieving an average RMSD of 2.49 Å on the Rosetta Antibody Benchmark.

OCD.py calculates inter-domain orientations for all immunoglobulin domains using a transferable approach, applicable to both single structures and molecular dynamics trajectories.

Ab-Ligity identifies sequence-dissimilar antibodies that bind to the same epitope by analyzing antibody-antigen interfaces, outperforming existing tools in precision and speed.

This paper uses residue-residue distance predictions to assess protein flexibility, finding that flexible residue pairs have more local maxima in their predicted distance distributions.