Author

Hilje M. Doekes

Wageningen University & ResearchORCID 0000-0002-6360-5176Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:metagenomics· 1

Frequent Co-Authors

Aditi BatraiD· 1 shared Anne KupczokiD· 1 shared Aryan Ramachandran· 1 shared J. Arjan G. M. de VisseriD· 1 shared Josia Pool· 1 shared Thomas E.P. de BruijniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperMicrobiology

Aditi BatraORCID

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2 papers

Recent·Most cited

Antibiotic tolerance due to filamentation shapes β-lactam pharmacodynamics in Escherichia coli

Aryan Ramachandran, Josia Pool, J. Arjan G. M. de Visser, Hilje M. Doekes, Aditi Batra

This study shows that cefotaxime has a two-step pharmacodynamic curve against E. coli due to filamentation and differential binding to penicillin-binding proteins, offering a mechanistic model for antibiotic action.

bioRxiv · Aug 26, 2026 · PreprintMicrobiology

Temperate versus virulent phage lifestyle impacts microdiversity in soil environments

Thomas E.P. de Bruijn, Hilje M. Doekes, Anne Kupczok

The paper analyzes viromics datasets to compare microdiversity between temperate and virulent phages in soil environments, finding higher microdiversity in temperate phages in most datasets.

ISME Communications · Jan 1, 2026Peer-reviewedGenomics