Aditi Batra

This study shows that cefotaxime has a two-step pharmacodynamic curve against E. coli due to filamentation and differential binding to penicillin-binding proteins, offering a mechanistic model for antibiotic action.

This study shows that increased collective β-lactam resistance in E. coli arises from activation of a dormant porin, NmpC, through an insertion sequence excision, enhancing drug permeability and filamentation.

The paper identifies negative hysteresis as a robust phenomenon in Pseudomonas aeruginosa that enhances antibiotic efficacy through increased aminoglycoside uptake after beta-lactam treatment.

This study shows that resistance variation and bacterial interactions influence the adaptation of a genetically diverse Pseudomonas aeruginosa population to antibiotic treatment.