J. Arjan G. M. de Visser

Antibiotic tolerance due to filamentation shapes β-lactam pharmacodynamics in Escherichia coli

This study shows that cefotaxime has a two-step pharmacodynamic curve against E. coli due to filamentation and differential binding to penicillin-binding proteins, offering a mechanistic model for antibiotic action.

Experimental evolution of collective β-lactam resistance in Escherichia coli via activation of a dormant outermembrane porin

This study shows that increased collective β-lactam resistance in E. coli arises from activation of a dormant porin, NmpC, through an insertion sequence excision, enhancing drug permeability and filamentation.

Contributions of intra- and extracellular antibioticdegradation to collective β-lactam survival

The paper investigates how intra- and extracellular β-lactamase activity contributes to collective β-lactam survival in E. coli under cefotaxime stress.

Anaerobic conditions increase plasmid transfer rates across Escherichia coli strains

This study shows that anaerobic conditions increase plasmid transfer rates in Escherichia coli strains, revealing oxygen blind spots in conventional conjugation assays.

Pyocyanin produced by Pseudomonas aeruginosa Creates Legacy Effects That Boost Antibiotic Resistance Evolution in Enterococci

The paper shows that exposure to pyocyanin from Pseudomonas aeruginosa increases antibiotic resistance evolution in enterococci through efflux mechanisms.

Microbial interactions affect the tempo and mode of antibiotic resistance evolution

This study shows that microbial interactions influence the rate and trajectory of antibiotic resistance evolution in uropathogens.